Neuromuscular Blockade
Conditions
Keywords
Acceleromyography, TOF-Watch, Posttetanic count, Train of four, Neuromuscular blockade
Brief summary
The purpose of this study is to examine the relationship between post-tetanic count (PTC) and time to first response to Train of four (TOF) stimulation during deep neuromuscular blockade induced by rocuronium.
Interventions
PROCEDUREPost-tetanic count frequency
Sponsors
Rigshospitalet, Denmark
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* ASA 1-3 * General anaesthesia \>1 hour * Surgery in supine position with possibility of monitoring the neuromuscular blockade at the thumb (n.ulnaris stimulation). * Written informed content
Exclusion criteria
* Neuromuscular disorders, hepatic and renal dysfunction * Medication expected to interfere with the neuromuscular blocking agent * Allergy to any medication used during anaesthesia * Body weight less or exceeding 20% of the ideal body weight * Pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to first response to TOF stimulation (T1) | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to second response to TOF stimulation (T2) | — |
| Time to first post-tetanic count (PTC) | — |
| Number of post-tetanic count at first response to TOF | — |
| Time to T1=25% | — |
| Interval 25-75% | — |
| Time to TOF 0.9 | — |
| Time to TOF 1.0 | — |
Countries
Denmark
Outcome results
None listed