Lymphoma
Conditions
Keywords
stage II adult Hodgkin lymphoma, stage III adult Hodgkin lymphoma, stage IV adult Hodgkin lymphoma, recurrent adult Hodgkin lymphoma
Brief summary
RATIONALE: Drugs used in chemotherapy, such as fludarabine and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. LMB-2 immunotoxin can find cancer cells and kill them without harming normal cells. Giving fludarabine and cyclophosphamide followed by LMB-2 immunotoxin may kill more cancer cells. PURPOSE: This clinical trial is studying how well giving fludarabine and cyclophosphamide followed by LMB-2 immunotoxin works in treating patients with Hodgkin's lymphoma.
Detailed description
OBJECTIVES: Primary * Determine the feasibility of pretreatment with fludarabine phosphate and cyclophosphamide in preventing neutralization of antibodies in patients with CD25-positive Hodgkin's lymphoma. Secondary * Determine the response rate in patients treated with LMB-2 immunotoxin. * Determine the response duration in patients receiving this treatment. * Correlate serum levels of LMB-2 immunotoxin with toxicity and response in these patients. * Assess the development of neutralizing antibodies and the effect of these antibodies on blood levels of LMB-2 immunotoxin and toxicity. * Correlate soluble Tac-peptide levels with treatment response in these patients. OUTLINE: This is a nonrandomized, pilot study. Patients receive fludarabine phosphate IV over 30 minutes and cyclophosphamide IV over 60 minutes on days 1-4 and filgrastim (G-CSF) subcutaneously once daily beginning on day 5 and continuing until blood counts recover. Beginning 4 weeks after completion of chemotherapy, patients receive LMB-2 immunotoxin IV over 30 minutes on days 1, 3, and 5. Treatment repeats every 28 days for up to 6 courses in the absence of disease progression. Blood is obtained prior to and after chemotherapy and then periodically during LMB-2 immunotoxin therapy for pharmacokinetic studies to measure lymphocyte subsets. PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.
Interventions
Sponsors
National Cancer Institute (NCI)
National Institutes of Health Clinical Center (CC)
Study design
Allocation
NON_RANDOMIZED
Primary purpose
TREATMENT
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Histopathologically confirmed CD25+ Hodgkin's lymphoma * At least 20% of the malignant cells positive by immunohistochemistry * Stage II-IV disease * Meets the following criteria: * Failed standard chemotherapy * Not eligible for curative salvage radiotherapy or chemotherapy * Not eligible for or refused bone marrow transplantation * Measurable disease * No patient whose serum neutralizes LMB-2 immunotoxin in tissue culture, due either to antitoxin or antimouse-IgG antibodies * No patient whose serum neutralizes \> 75% of the activity of 1 µg/mL of LMB-2 immunotoxin PATIENT CHARACTERISTICS: * ECOG performance status 0-2 * Absolute neutrophil count ≥ 1,000/mm³ * Platelet count ≥ 50,000/mm³ * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception * ALT and AST ≤ 2.5 times upper limit of normal * Albumin ≥ 3.0 g/dL * Bilirubin ≤ 2.2 mg/dL (\< 5 mg/dL if Gilbert's syndrome is present) * Creatinine ≤ 1.4 mg/dL OR creatinine clearance ≥ 50 mL/min * No uncontrolled intercurrent illness including, but not limited to, any of the following: * Ongoing or active infection * Symptomatic congestive heart failure * Unstable angina pectoris * Cardiac arrhythmia * Psychiatric illness or social situations that would limit study compliance * No HIV or hepatitis C positivity * Hepatitis B surface antigen positivity allowed provided patient is receiving lamivudine * LVEF ≥ 45% * DLCO ≥ 50% of normal OR FEV\_1 ≥ 60% of normal * No active second malignancy requiring treatment PRIOR CONCURRENT THERAPY: * See Disease Characteristics * No systemic cytotoxic chemotherapy within the past 4 weeks * No systemic steroids (except stable doses of prednisone ≤ 20 mg/day) within the past 4 weeks * No monoclonal antibody therapy within the past 12 weeks * No prior LMB-2 immunotoxin * No concurrent warfarin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feasibility of using fludarabine phosphate and cyclophosphamide to decrease neutralizing antibodies | — |
Secondary
| Measure | Time frame |
|---|---|
| Response rate | — |
| Response duration | — |
| Correlation of serum levels of LMB-2 immunotoxin with toxicity and response | — |
| Development of neutralizing antibodies and its effect on blood level of LMB-2 immunotoxin and toxicity | — |
| Correlation of soluble Tac-peptide with treatment response | — |
Countries
United States
Outcome results
None listed