A Study to Evaluate the Safety and Efficacy of an Investigational Drug in the Treatment of Postoperative Dental Pain (MK-2295-005)

A Randomized Double-blind, Placebo-and Active Comparator-Controlled 2-Part Study to Evaluate the Efficacy of MK2295 in Patients With Postoperative Dental Pain

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00387140

Enrollment

Registered

2006-10-12

Start date

2006-10-31

Completion date

2007-05-31

Last updated

2015-11-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain, Postoperative, Tooth Extraction

Keywords

Dental Pain, Postoperative

Brief summary

This study is being conducted to evaluate the safety and tolerability of the drug and to evaluate its efficacy compared to placebo and to ibuprofen in the treatment of postoperative dental pain in male patients.

Interventions

DRUGMK2295

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

MALE

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients in generally good health who are scheduled to have two or more third molars removed, at least one of which is partially or completely embedded in bone and is a mandibular impaction

Exclusion criteria

* Patient has a temperature of 37.5C or greater prior to dosing * Patient has participated in another clinical study within the last 4 weeks

Design outcomes

Primary

Measure	Time frame
Peak analgesic response, safety, and tolerability	Over 24 Hours

Secondary

Measure	Time frame
Onset of analgesia, duration of analgesia	Over 24 Hours

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026