Metabolic Study of Concentric and Eccentric Muscle Training

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00386854

Enrollment

Registered

2006-10-12

Start date

2003-04-30

Completion date

2003-08-31

Last updated

2006-10-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammation, Insulin Resistance, Lipid Metabolism

Keywords

exercise, lipid metabolism, lipoproteins, insulin resistance, inflammation

Brief summary

The purpose of this study is to evaluate the metabolic and anti-inflammatory effects of eccentric endurance exercise and to compare them with those of concentric exercise in healthy sedentary individuals.

Detailed description

Physical exercise decreases the risk of obesity, diabetes mellitus, and cardiovascular disease. Skeletal muscle can be exercised by two ways: Concentric contraction is defined as active shortening of muscles, e.g. by stepping upwards, whereas eccentric muscle contraction is defined as active resistance to stretching, e.g. by stepping downwards. Although the effects of exercise (i.e. the combination of concentric and eccentric muscle contraction) on metabolic parameters have been extensively investigated, there are no data on the specific metabolic effects of concentric versus those of eccentric muscle work in humans. Comparison(s): Metabolic and anti-inflammatory effects of eccentric endurance exercise (i.e. stepping upwards), compared to metabolic and anti-inflammatory effects of concentric exercise (i.e. stepping downwards).

Interventions

BEHAVIORALphysical training

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

ECT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

30 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* healthy men and women * age over 30 years

Exclusion criteria

* previous systematic endurance training (≥3 times per week ≥30 min) * body mass index \>30 kg/m2 * heavy smoking (\>20 cigarettes per day) * regular alcohol consumption \>60g per day * established musculoskeletal disease * history of cardiovascular disease * diabetes mellitus * unwillingness to stay in the area for the whole study period

Design outcomes

Primary

Measure	Time frame
Metabolic and anti-inflammatory effects induced by eccentric muscle exercise.	—

Secondary

Measure	Time frame
Metabolic and anti-inflammatory effects induced by concentric muscle exercise.	—

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 22, 2026