Abortion, Induced
Conditions
Brief summary
Data from other countries have suggested that oral mifepristone used as a cervical ripening agent may decrease induction to delivery time in midtrimester inductions. To our knowledge, there are no trials comparing mifepristone to laminaria in a standard clinical setting with standardized misoprostol induction protocol to examine the issue of induction to delivery time. We hypothesize that mifepristone will work at least as well as laminaria for midtrimester cervical ripening prior to induction of labor with misoprostol.
Interventions
DRUGmifepristone
Sponsors
Dartmouth-Hitchcock Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
16 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* pregnant women with fetal anomalies, aneuploidy, or demise at 15-22 weeks gestation * age greater than 16 * able to speak English
Exclusion criteria
* prior uterine scar or * allergy or history of bad reaction to any of the study drugs or * history of chronic adrenal failure or * porphyria or * concurrent long-term corticosteroid treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| induction to delivery time | — |
Secondary
| Measure | Time frame |
|---|---|
| pain | — |
| delivery within 24 hours | — |
| need for post-partum D&C | — |
| adverse events | — |
Countries
United States
Outcome results
None listed