Refractory Frontal Lobe Epilepsy
Conditions
Keywords
repetitive transcranial magnetic stimulation, low frequency, frontal lobe epilepsy, brain excitability, electromyography
Brief summary
Epileptic disease is characterised by enhanced brain excitability. Low frequency repetitive transcranial magnetic stimulation (rTMS) can be an effective treatment for refractory frontal epilepsy. Thought, physiological mechanisms of its effectivity are still unknown. It is yet possible to evaluate cortical excitability and inhibition with TMS-coupled electromyography before and after rTMS sessions ; this could provide clues for basic mechanisms of rTMS effects on the epileptic brain. We assume that rTMS decrease brain excitability by improving brain inhibition. Such an information could help for treating patients with both pharmacological and non-pharmacological methods.
Interventions
DEVICEcortical magnetic stimulation provided by an eight-shaped coïl placed upon the skull.
Sponsors
University Hospital, Strasbourg, France
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
12 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Cryptogenic frontal lobe epilepsy * Normal cerebral MRI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Electrophysiological parameters for cortical excitability measured just before and after rTMS, 4 hours later and 24 hours later. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical efficacity on seizure intensity and frequency. | — |
Countries
France
Outcome results
None listed