Coronary Heart Disease
Conditions
Keywords
Alcohol, Red wine, Endothelial function, Flow-mediated vasodilation, Cardiovascular disease
Brief summary
To study the effect of red wine, beer and fruit juice on endothelial function in patients with coronary Heart disease.
Interventions
BEHAVIORALModerate daily consumption of Red wine
BEHAVIORALModerate daily consumption of beer
BEHAVIORALModerate consumption of fruit juice rich in polyphenolics
Sponsors
Aalborg University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Men or postmenopausal women with stable coronary heart disease * Coronary heart disease should be verified by coronary angiography with at least 50% stenosis in at least one coronary vessel.
Exclusion criteria
* Patients with myocardial infarction within the last tree months * Persons with a present or earlier alcohol abuse * Persons with a present or earlier drug abuse * Person with malign disease * Persons, that we consider unsuitable to carry through the examines.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in flow-mediated vasodilation after 2 weeks intervention compared with baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| Effects in Coagulation factors after 2 weeks intervention | — |
| Effects on markers of inflammation after 2 weeks intervention | — |
| Effects on markers of endothelial function after 2 weeks intervention | — |
| Changes in the overall antioxidant activity in plasma after 2 weeks intervention | — |
| Lipid status after 2 weeks intervention compared with baseline | — |
Countries
Denmark
Outcome results
None listed