Barrier Function and Production of Inflammatory Cytokines in the Rectal Mucosa in Patients With Septic Shock

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00378586

Enrollment

Registered

2006-09-20

Start date

2010-01-31

Completion date

Unknown

Last updated

2009-06-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic Shock

Brief summary

Life-threatening infection impairs bloodflow to the gut, thereby causing less delivery of oxygen. This leads to increased formation of different inflammatory and infectious markers. The investigators hypothesize, therefore, that there is a significant difference in the concentrations of inflammatory and infectious markers in the rectal mucosa between patients with septic shock and healthy controls.

Interventions

PROCEDURERectal biopsy

Rectal biopsy.

PROCEDUREMeasurement of inflammatory markers in the rectal mucosa

IL-6, TNF-alfa.

PROCEDUREMeasurement of rectal lactic acid

Equilibrium dialysis.

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Septic shock

Exclusion criteria

* Age \< 18 years * No next of kin * Pathology of the descending or sigmoid colon or rectum * Pregnancy * 1st degree relatives with inflammatory bowel disease * Severe coagulopathy

Countries

Denmark

Contacts

Primary ContactMichael Ibsen, MD

micibs@dadlnet.dk+ 45 45 35 94 18

Backup ContactAnders Perner, MD, PhD

ap@dadlnet.dk+ 45 45 35 41 31

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026