Elderly
Conditions
Keywords
catechin, elderly, mouth washing, disabled, colonized
Brief summary
The Purpose of this study is to evaluate the effects of catechin mouth-washing on the removal of intraoral bacteria in the elderly
Detailed description
Catechins are the major components of tea flavonoids and recent in vitro experimental studies have revealed that tea catechin extracts induce bactericidal effects. However, a limited number of studies have been conducted on the clinical effects of tea catechin against bacterial infection and also the effects in the elderly is unclear. Based on these backgrounds, we designed a prospective randomized controlled study to evaluate the effects of catechin mouth washing on oral pathogenic bacterial detected in the elderly.
Interventions
DIETARY_SUPPLEMENTcatechin extracts
catechin extracts solution
Sponsors
Masahiro Morikawa
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
65 Years to 95 Years
Healthy volunteers
No
Inclusion criteria
* aged over 65 years * detected oral pathogenic bacterium and revalidated during the wash-out period * without antibacterial medicine, other mouth-washing remedies during the study * Obtained written informed consent before participation
Exclusion criteria
* possessing some infectious diseases in need of therapy * possessing tea or catechin allergy * diagnosed as inadequate for other reasons to participate the study by principal investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Removal of intraoral pathogenic bacteria identified before the study | After intervention |
Secondary
| Measure | Time frame |
|---|---|
| Reduction of intraoral bacteria after the study | After intervention |
Countries
Japan
Outcome results
None listed