Removal of Protein Bound Uremic Toxins by Modified Plasma Separation and Adsorption Combined With Hemodialysis

Removal of Protein Bound Uremic Toxins in Chronic Hemodialysis Patients by Modified Plasma Separation and Adsorption Combined With Hemodialysis

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00375635

Enrollment

Registered

2006-09-13

Start date

2006-03-31

Completion date

2006-10-31

Last updated

2006-09-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Uremia

Keywords

mFPSA, Uremic toxins, Protein bound toxins, Uremia, Chronic hemodialysis

Brief summary

The aim of this study is to examine removal of protein bound uremic substances by mFPSA in chronic hemodialysis patients. mFPSA is an extracorporal blood purification system developed for detoxification in acute liver failure by removal of protein bound as well as water soluble substances.

Detailed description

Measurements of uremic protein bound substances before and after mFPSA and a preceding routine hemodialysis session.

Interventions

PROCEDUREmFPSA treatment

Study design

Allocation

NON_RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Over the age of 18 * Anuria * Chronic hemodialysis dependence

Exclusion criteria

* No present history of bleeding episodes * Cardiac diseases

Design outcomes

Primary

Measure	Time frame
Concentrations of protein bound uremic toxins	—
Blood pressure	—
Safety serological parameters	—

Secondary

Measure	Time frame
Bleeding episodes	—

Countries

Denmark

Contacts

Primary ContactMette B Damholt, MD,Ph.d.

damholt@dadlnet.dk+45 35453545

Backup ContactSoren D Ladefoged, MD

SOERENRH04736LADEFOGED@rh.dk+45 35453545

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026