Autistic Disorder
Conditions
Keywords
Autism, Applied Behavioral Analysis, Risperidone
Brief summary
Hypotheses: 1. Preschool children with autism spectrum disorders (ASDs) who undergo ABA treatment only will demonstrate significantly better outcomes compared to an age and severity matched control group without ABA treatment. 2. Preschool children with ASDs who undergo ABA in combination with risperidone will demonstrate significantly better outcomes compared to age and severity matched children who are receiving ABA alone. 3. Young age, cognitive development and attentional abilities at baseline will be predictive of good socio-emotional and neuropsychological outcomes after ABA treatment. 4. At baseline, children with ASDs will show significantly lower performances on measures of cognitive, neuropsychological, and socio-emotional functioning than age-matched typically developing controls.
Interventions
DRUGRisperidone
BEHAVIORALABA
Sponsors
Washington University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
30 Months to 5 Years
Healthy volunteers
Yes
Inclusion criteria
* Diagnosis of autism or severe pervasive developmental disorder (PDD) not otherwise specified (NOS) according to the Autism Diagnosis Interview-Revised (ADI-R) * Aged 2.6 to 5.0.
Exclusion criteria
* Fragile X or metabolic etiology of PDD symptoms * Diagnosis of other central nervous system (CNS) disorders * Chronic serious medical problems
Countries
United States
Outcome results
None listed