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Effects of an Alternative Treatment for Military Sexual Trauma on PTSD Symptoms, Neurosteroids and Brain Function

Effects of an Alternative Treatment for Military Sexual Trauma on PTSD Symptoms, Neurosteroids and Brain Function

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00374738
Enrollment
34
Registered
2006-09-11
Start date
2006-11-30
Completion date
2008-09-30
Last updated
2016-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stress Disorders

Keywords

Guided Imagery for Trauma (GIFT), Posttraumatic Stress Disorder (PTSD), Military Sexual Trauma (MST), Military Sexual Trauma - related PTSD

Brief summary

Our specific aims are: 1. To examine the efficacy of GIFT in improving MST-related clinical outcomes in women veterans 2. To examine the effects of GIFT on fronto-limbic brain function and 3. To examine the effects of GIFT on levels of neuroactive steroid associated with PTSD.

Detailed description

Guided imagery is a complementary and alternative treatment (CAM) modality. This directed meditation technique uses healing imagery to promote recovery in a variety of illnesses, including cancer, heart disease and, more recently, posttraumatic stress disorder (PTSD). PTSD is a severe and disabling anxiety disorder. It is among the most common mental disorders, affecting 10% of women in the United States during their lifetime. Sexual assault is the most common cause of PTSD. Similarly, military sexual trauma (MST) is disturbingly common among women in the armed forces. At least 20% of women veterans using VA services report a history of sexual assault. Unfortunately, high rates of MST-related PTSD are anticipated among women currently deployed to Iraq and Afghanistan. To address this issue, we will evaluate a guided imagery intervention for women veterans who have MST-related PTSD. We will evaluate the efficacy of Guided Imagery for Trauma (GIFT) in decreasing PTSD symptoms. Using brain-imaging techniques, this research will examine the effects of GIFT on brain function in the areas associated with PTSD. We will also examine the effects of GIFT on neurosteroids, which are candidate modulators of PTSD symptoms, and may also represent novel targets for therapeutic intervention.

Interventions

BEHAVIORALGuided Imagery for Trauma (GIFT)

Guided Imagery for Trauma (GIFT) - music and voice narration over a 12-week intervention. The control intervention included a relaxing music audio (the same music used in the guided imagery audio but without the narrative voiceover), PDA to log audio use, orientation and weekly phone consults, but did not have access to the patient advocate or to the guided imagery instructions provided on the GIFT audio.

Sponsors

Duke University
CollaboratorOTHER
Durham VA Medical Center
CollaboratorFED
Samueli Institute for Information Biology
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* Aged 18-65 * Status as a woman veteran * Receives care at the Durham VAMC * History of MST * DSM-IV diagnosis of PTSD, confirmed by CAPS interview * Able to participate in a research interview in English * Regular telephone access

Exclusion criteria

* Current diagnosis of organic or psychotic mental disorder * Suicidality or parasuicidality * Ongoing family violence * Alcohol or drug dependence within previous 3 months * Enrolled in cognitive-behavioral/exposure-based therapy during study period. * Supportive therapy and psychiatric medications (if stabilized at least 3 months prior to enrollment) are acceptable. * An uncontrolled medical condition

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026