Infertility
Conditions
Brief summary
The purpose of this study is to test if recombinant follicle stimulating hormone (rFSH) given in individual doses, according to a nomogram we have constructed based on our results from a previous study, results in more patients maturing 2-3 follicles compared to standard dose.
Interventions
DRUGrFSH drug dose
Individual rFSH dose (50, 75 or 100 IU rFSH/day)
DRUGStandard rFSH dose
Standard rFSH dose was 75 IU/day
Sponsors
Nina la Cour Freiesleben
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
25 Years to 39 Years
Healthy volunteers
No
Inclusion criteria
* Age between 25-39 years * First stimulation with rFSH only * Indication for intrauterine insemination with standard rFSH starting dose * Regular menstrual bleeding with a cycle between 21-35 days * Two ovaries * Bilateral tuba patency * Semen analysis must be sufficient for insemination according to the diagnostic analysis.
Exclusion criteria
* More than three former stimulated intrauterine insemination cycles
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of mature follicles in the study and control group. | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of cycles where the rFSH dose is changed. | — |
| Number of cycles cancelled or converted to in vitro fertilisation. | — |
| Pregnancy rate. | October 2008 |
Countries
Denmark
Outcome results
None listed