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The Effect of Erythromycin on Occurrence of Leaks From Cervical Esophageal-Gastric Anastomosis After Trans-Hiatal Esophagectomy

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00373919
Enrollment
Unknown
Registered
2006-09-08
Start date
Unknown
Completion date
Unknown
Last updated
2007-03-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophagectomy, Postoperative Complications

Brief summary

Cervical anastomotic leak is one of the most common complications after trans-hiatal esophagectomy. Hypothesis: An early post operative administration of a pro-kinetic dosage of erythromycin will reduce leak occurrence. Design: This is a prospective, randomized, double blind, placebo controlled study. Number of patients: 30. Inclusion Criteria: * Patients after trans-hiatal esophagectomy Exclusion Criteria: * Allergy to erythromycin * Use of phenothiazine * QT prolongation * Liver function test (LFT) abnormalities * Myasthenia gravis * Cardiomyopathy

Interventions

DRUGintravenous (IV) administration of erythromycin

Sponsors

Kaplan Medical Center
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
DOUBLE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Patients after trans-hiatal esophagectomy

Exclusion criteria

* Allergy to erythromycin * Use of phenothiazine * QT prolongation * Liver function test (LFT) abnormalities * Myasthenia gravis * Cardiomyopathy

Contacts

Primary ContactYoram Klein, MD
yoramkl@clalit.org.il972-50-8213221

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026