The Use of Nasal Phenylephrine in Infants With Bronchiolitis

A Randomized, Double-Blinded Placebo Control Trial of Nasal Phenylephrine in Infants With Bronchiolitis

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00373802

Enrollment

Registered

2006-09-08

Start date

2005-01-31

Completion date

2005-06-30

Last updated

2009-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchiolitis

Brief summary

Drops of either saline or phenylephrine are placed in the nose of infants less than 12 months of age to determine if it helps them to breathe easier.

Interventions

DRUGPhenylephrine

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

4 Weeks to 12 Months

Inclusion criteria

* Age 4 weeks to 12 months; admitting diagnosis of bronchiolitis; admitted to hospital's bronchiolitis pathway, admitted during weekdays, need for nasal suctioning.

Exclusion criteria

* Congenital heart disease, history of hypertension, previous wheezing, prior use of inhaled corticosteroids, gestational age at birth of \<34 weeks.

Design outcomes

Primary

Measure	Time frame
Respiratory Distress Assessment Index at 5 minutes, 60 minutes, and 180 minutes.	—

Secondary

Measure	Time frame
Respiratory rate, oxygen saturation and use of supplemental oxygen at 5, 60, and 180 minutes.	—

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026