Dry Eye Syndromes
Conditions
Keywords
contact lenses, intolerance, punctal plugs, tear volume, Intolerance to contact lens wear due to dryness symptoms
Brief summary
The purpose of this study is to evaluate the role of tear volume in discomfort and dryness sensations during contact lens wear, and the possible influence on osmolality and ocular surface sensitivity.
Detailed description
50% of contact lens wearers have dryness/discomfort during contact lens wear. Significant decreases in lipid layer and tear film break up time during contact lens wear have been reported, leading to excessive evaporation, reduced tear volume and an increase in osmolality. Similar tear film changes occur with Dry Eye Disease. A commonly used therapy in treating dry eye is the insertion of punctal plugs to increase tear volume and ease dry eye symptoms. Punctal plugs block the tear drainage system, and often increase tear stability, and improve ocular surface health. This study will evaluate the role of tear volume in discomfort and dryness sensations during contact lens wear, and the possible influence on osmolality and ocular surface sensitivity. Collagen punctal plugs will be used for this study, as these allow a temporary (3-14 days) occlusion of the ocular drainage system, are easily removed if necessary and are inserted with minimal risk.
Interventions
DEVICETemporary Collagen Inserts
Sponsors
The University of New South Wales
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 64 Years
Healthy volunteers
Yes
Inclusion criteria
* Over 18 years of age
Exclusion criteria
* Corneal refractive surgery * Contraindications to contact lens wear * Latex allergy * Corneal hypoesthesia * Active corneal infection * Acute or sub-acute inflammation or infection of the anterior chamber of the eye
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ocular comfort after 6 hours of contact lens wear | — |
| Dryness sensation after 6 hours of contact lens wear | — |
| Tear film volume before and after 6 hours of contact lens wear | — |
Secondary
| Measure | Time frame |
|---|---|
| Objective ocular sensitivity after 6 hours of contact lens wear | — |
| Tear film and contact lens osmolality after 6 hours of contact lens wear | — |
Countries
Australia
Outcome results
None listed