Periodontitis
Conditions
Keywords
chronic periodontitis, mouth, Moderate to advanced chronic periodontitis
Brief summary
The purpose of this study is to measure the antimicrobial effects of Arestin in subjects with moderate to advanced periodontal disease
Interventions
Sponsors
OraPharma
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE
Eligibility
Sex/Gender
ALL
Age
30 Years to 65 Years
Inclusion criteria
* Generalized moderate to advanced chronic periodontitis, five sites with probing depths of \>5 mm in 5 non-adjacent interproximal spaces, excluding the distal of terminal teeth, at least 16 teeth excluding 3rd molars and implants
Exclusion criteria
* Allergy to tetracycline * Subjects with aggressive periodontitis * Acute necrotizing ulcerative gingivitis, or gross decay * Systemic conditions which could influence the course of periodontal disease (i.e, diabetes, autoimmune disease, etc) * Individuals requiring prophylactic antibiotics * Any periodontal therapy within the previous 3 months (excluding maintenance therapy) * Systemic or local antibiotic therapy within three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in the mean sum of primary pathogens (P. gingivalis, To forsythensis, and T. denticola) from baseline to 30 days. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the numbers of each of the primary pathogens, changes in pocket depth, attachment level, and proportion of sites bleeding on probing | — |
Countries
United States
Outcome results
None listed