The Effect of 5-FU and LMW Heparin on the Rate of Retinal Redetachment After Silicone Oil Removal in Cases of PVR

Status

UNKNOWN

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00371020

Enrollment

Unknown

Registered

2006-09-01

Start date

2005-02-28

Completion date

2007-07-31

Last updated

2007-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Proliferative Vitreoretinopathy

Keywords

silicone oil, PVR, retinal redetachment, low molecular weight heparin, 5-FU

Brief summary

To evaluate the effect of combined 5-FU and low molecular weight heparin in infusion on the rate of retinal redetachment after silicone oil removal in cases of proliferative vitreoretinopathy (PVR).

Interventions

DRUGlow molecular weight heparin, 5-FU

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

MALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Cases with history of vitrectomy and silicone oil injection for management of PVR who undergo silicone oil removal

Exclusion criteria

* any sign of retinal redetachment before silicone oil removal * any sign of diabetic retinopathy

Design outcomes

Primary

Measure	Time frame
Retinal redetachment rate	—

Secondary

Measure	Time frame
visual acuity	—
intraocular pressure	—
reoperation	—
relative afferent pupillary defect	—

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026