Oral Colchicine Combined With Intravitreal Infusion of Dexamethasone, LMW Heparin and 5-FU for Management of Proliferative Vitreoretinopathy (PVR)

Status

UNKNOWN

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00370760

Enrollment

Unknown

Registered

2006-09-01

Start date

2006-09-30

Completion date

Unknown

Last updated

2008-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Proliferative Vitreoretinopathy

Keywords

PVR, Oral colchicine, Dexamethasone, low molecular weight heparin, 5-FU

Brief summary

To evaluate the efficacy of oral colchicine combined with intraoperative infusion of dexamethasone, low molecular weight heparin and 5-FU during vitrectomy for management of established proliferative vitreoretinopathy (PVR)

Interventions

DRUGoral colchicine, dexamethasone, low molecular weight heparin, 5-FU

DRUGplacebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

MALE

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Cases with rhegmatogenous retinal detachment complicated by PVR grade C

Exclusion criteria

* History of pars plana vitrectomy for PVR grade C * History of silicone oil injection * History of ocular trauma * Diabetic retinopathy * Glaucoma * Giant retinal tear

Design outcomes

Primary

Measure	Time frame
Retinal reattachment rate	—

Secondary

Measure	Time frame
PVR recurrence,	—
macular pucker,	—
reoperation,	—
ocular hypotony,	—
visual acuity	—

Countries

Iran

Contacts

Primary ContactHamid Ahmadieh, MD

hahmadieh@hotmail.com+98 21 22585952

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026