Heart Valve Diseases, Hyperglycaemia During Perioperative Period, Ventricular Dysfunction
Conditions
Keywords
hyperglycaemia, open heart surgery, intensive care unit
Brief summary
The purpose of the study is to seek if there is difference to state glucose level in 80-120mg/dl or 200mg/dl in patients submitted to open heart surgery
Detailed description
Hyperglycaemia in the intensive care unit and perioperative period has been accused to be one of the causes of worse clinical outcome. It is known that in open heart surgeries the glucose level must be set less than 200mg/dl, but new trials had set the glucose level lower than that: 140mg/dl in some studies and even lower (80-110mg/dl). Our trial had the intention to seek if there is difference setting glucose level in 2 different ones would modifies clinical outcome.
Interventions
Sponsors
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* adult more than 21 years old * open heart surgery with cardiopulmonary bypass
Exclusion criteria
* renal dysfunction * reoperation * use of inotropic support * neurological dysfunction * chronic pulmonary obstructive disease * emergency or urgency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of intubation | — |
| ICU length | — |
| Blood transfusion | — |
| Infection rate | — |
| Renal dysfunction | — |
| Neurological dysfunction | — |
| Hospital length | — |
| Mortality | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of surgery | — |
| Length of cardiopulmonary bypass | — |
| Physical status | — |
| EuroSCORE | — |
| Parsonnet | — |
| Canadian Multicenter index | — |
Countries
Brazil
Outcome results
None listed