Energy Homeostasis in Anorexia Nervosa

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00368667

Enrollment

120

Registered

2006-08-25

Start date

2000-04-30

Completion date

2004-12-31

Last updated

2010-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anorexia Nervosa

Keywords

Anorexia Nervosa, Body Composition, Metabolic Rate

Brief summary

The purpose of this study is to investigate the potential biological predispositions that contribute to the difficulty patients with anorexia nervosa have in maintaining normal weight.

Detailed description

Anorexia Nervosa (AN) is a psychiatric illness that is characterized by extreme weight loss and severe body image distortions. In this study, we are examining changes in body composition, metabolic rate, and reproductive function before and after treatment for AN. More specifically, we are testing the hypotheses that 1)Weight-restored patients with AN have elevated resting energy expenditure (REE) compared to controls, 2) Weight-restored patients with AN have a central disposition of body fat compared to controls, 3) Weight-restored patients with AN who gain the most fat centrally will have the least improvement on psychological measures, 4) Weight-restored patients with AN will have leptin levels out of proportion to body fat mass. It will also investigate the relationship between REE and leptin with respect to the return of menses.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

Patients: Inclusion Criteria: * DSM-IV diagnosis of Anorexia Nervosa * BMI ≤ 17.5kg/m2 (equivalent to 80% of ideal body weight) * Medically stable * Participation in in-patient treatment sufficient to restore patient to a BMI of at least 19kg/m2

Exclusion criteria

* On medication\* * Current substance abuse or dependence * History of suicide attempt or other self-injurious behavior within the previous 6 months * Non-removable metal on/in their body (e.g. metal pacemaker, surgical clips, metallic-ink tattoos) Controls: Inclusion criteria: * No current psychiatric disorder (including eating disorder, depression, bipolar disorder, schizophrenia, substance abuse/dependence) * No history of an eating disorder * BMI greater than 19kg/m2 and less than 21kg/m2 * Weight stable (+/- 2kg) for the previous 6 months * No history of excessive or repeated dieting * No history of excessive exercise (defined as greater than 6 hours/week) * Regular menstrual cycles

Countries

United States

Outcome results