Ovarian Cancer
Conditions
Keywords
ovarian cancer, recurrence, surgery
Brief summary
The purpose of this study is to validate a score developed by the AGO-OVAR for complete resection of the tumor
Detailed description
The multicentre retrospective study AGO-DESKTOP OVAR 1 investigated in a multicentre-setting the question of prognostic factors for a successful (i.e. complete) debulking for recurrence. That way, a hypothesis for a score with 3 factors could be developed: * PS ECOG = 0 * tumor-free after primary surgery (if unknown: FIGO I/II) * Ascites \< 500 ml. The goal of this study is to evaluate in a prospective multicentre setting, to what extent this retrospectively defined AGO-score has predictive validity. The criterion aimed at is therefore the rate of complete tumor resections if the three score characteristics are present in invasive epithelial platinum-sensitive ovarian-, fallopian tube- or primary peritoneal cancer. This study will be the second in a series of three: (1) hypothesis building for a potential predictive score for resectability, (2) prospective confirmation of the AGO-score, and (3) application of the AGO-score as inclusion criteria for eligible patients in whom a formal comparison of the role of secondary debulking of relapsed ovarian cancer could be performed.
Interventions
None listed
Sponsors
Arbeitsgemeinschaft Gynaekologische Onkologie Austria
MITO
AGO Study Group
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with recurrence of invasive epithelial ovarian-, fallopian tube- or primary peritoneal cancer of any initial stage who have relapsed after a tumor-free interval of at least 6 months after completion of first-line therapy. The same interval applies to patients with second relapse who are enrolled after completed platinum-containing re-induction therapy. * Women aged \> 18 years * Patients who have given their signed and written informed consent to data transmission and -processing
Exclusion criteria
* Patients with non-epithelial tumors as well as borderline tumors * Patients who undergo second-look surgery or completion surgery after end of chemotherapy or during the interval * Only for the study collective: patients with second malignancies who have been treated by laparotomy, as well as other neoplasias, if the treatment could interfere with the treatment of relapsed ovarian cancer * Patients with a third recurrence * Patients with so-called platinum-refractory tumor, i.e. progression during chemotherapy or recurrence within 6 months after end of former platinum-containing therapy
Countries
Austria, Belgium, Germany, Italy
Outcome results
None listed