Acute Obliterating Bronchiolitis, Bronchiolitis Obliterans
Conditions
Brief summary
We looked for the effectiveness of low-dose long-term prescription of erythromycin in mustard-induced bronchiolitis obliterans
Interventions
DRUGErythromycin
Sponsors
Baqiyatallah Medical Sciences University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
MALE
Inclusion criteria
* Documented chemical exposure * Clinical, spirometric and radiological findings were compatible with BO on High Resolution Computed Tomography (HRCT) * Non-responsiveness to high dose bronchodilator therapy
Exclusion criteria
* Radiographic evidence of pneumonia, active tuberculosis, lung carcinoma, or an infection that necessitated the use of an antibiotic * History of cigarette smoking and occupational exposure to toxic agents of hypersensitivity to macrolides * History of treatment with a systemic antibiotic within 7 days before the start of the study * Any investigational medicine within 4 weeks of the study * History of antibiotic injection within 6 weeks before the study * Concomitant Theophylline or Carbamazepine, unless their serum concentrations were regularly monitored * Patients who were in the exacerbation phase of their respiratory complications * Need to use medications interact with macrolides such as Digoxin, Theophylline and Carbamazepine * Systemic antibiotics * Systemic Corticosteroids * Admission to the hospital * Abnormal kidney or liver function
Countries
Iran
Outcome results
None listed