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Molecular Epidemiology of Benzene-exposed Workers.

Molecular Epidemiology of Benzene-exposed Workers in Shanghai,China

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT00364520
Enrollment
2000
Registered
2006-08-15
Start date
2003-08-31
Completion date
2009-12-31
Last updated
2015-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hematologic Diseases

Keywords

Hematologic Diseases, Benzene, Genetic Polymorphisms

Brief summary

The purpose of this study is to investigate the health effects of benzene exposure in workers in Shanghai, China.

Detailed description

The purpose of this study is to investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers and to characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity.

Interventions

OTHERShanghai workers

Sponsors

Fudan University
CollaboratorOTHER
University of Cincinnati
CollaboratorOTHER
ExxonMobil Biomedical Sciences, Inc.
CollaboratorINDUSTRY
British Petroleum P.L.C.
CollaboratorINDUSTRY
Chevron Corporation
CollaboratorINDUSTRY
ConocoPhillips
CollaboratorINDUSTRY
Exxon Mobil
CollaboratorINDUSTRY
Marathon Ashland
CollaboratorUNKNOWN
Shell Chemicals
CollaboratorINDUSTRY
University of Colorado, Denver
Lead SponsorOTHER

Study design

Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
18 Years to 67 Years
Healthy volunteers
Yes

Inclusion criteria

Worked for at least one year in a monitored environment Have at least one physical examination recorded \-

Exclusion criteria

History of cancer, radiation exposure, chemotherapy \-

Design outcomes

Primary

MeasureTime frameDescription
Investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers.August 2003 - December 2009Investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers

Secondary

MeasureTime frameDescription
Characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity.August 2003 - December 2009Characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026