A Low Glycemic Load Diet During Pregnancy in Overweight Women

Glycemic Load and Infant Birth Weight in Pregnant Overweight/Obese Women

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00364403

Enrollment

Registered

2006-08-15

Start date

2007-02-28

Completion date

2010-02-28

Last updated

2010-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Overweight, Pregnancy

Keywords

Glycemic index, Glycemic load, Low fat, Impaired glucose tolerance, Large for gestational age infant, Excessive body weight

Brief summary

This study will compare the effects of a low glycemic load versus standard diet for pregnancy on outcomes related to risk for obesity, diabetes, and heart disease in both mother and infant.

Interventions

BEHAVIORALLow glycemic load

Provision of foods and dietary counseling to promote a low glycemic load diet

BEHAVIORALLow fat diet

Provision of foods and dietary counseling to promote a low fat diet

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

25 Years to No maximum

Healthy volunteers

Inclusion criteria

* Pregnant women with prepregnant or first trimester BMI equal to or greater than 25 kg/m2 and less than 45 kg/m2 * Singleton pregnancy * Willing to consume the diets for duration of pregnancy * Participant to be at week 28 or less of pregnancy at baseline visit

Exclusion criteria

* Smoking during pregnancy * Major medical illness (e.g., diabetes mellitus, hypertension, thyroid disease) * Patients taking prescription medication known to affect body weight * Alcohol consumption during pregnancy * Patients who declare their intention to deliver infants in the environment outside of Beth Israel Deaconess Medical Center, Boston * High level of physical activity

Design outcomes

Primary

Measure	Time frame
Birth weight as assessed by z-scores	At birth

Secondary

Measure	Time frame
Infant body composition (ponderal index, skinfold thickness)	At birth
Maternal energy intake	During pregnancy
Maternal weight gain	During pregnancy
Maternal metabolic syndrome components	During pregnancy
Cord blood glucose	At birth
cord blood insulin	At birth
cord blood leptin	At birth
Maternal insulin resistance assessed by HOMA	During pregnancy

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 30, 2026