Migraine
Conditions
Brief summary
After infusion / injection of Glyceryl trinitrate and Diamox it is wished to study the effect of drugs on the cerebral haemodynamics such as Cerebral blod flow and cerebral blod volume.
Detailed description
Experimental headache model open a unike opportunity to study the pathophysiological mechanisms behind headache in general and migrane in particular. Previous studies have used various techniques to study the cerebral haemodynamics as a basis for the headache pathophysiology. We wish to use a 3-Tesa MRI so study the cerebral haemodynamics after application of various pharmacological substances. The most used experimental headache model is the glyceryl trinitrate model (GTN). Where infusion of the NO donor GTN induces headache and changes in the cerebral arteries. On the other hand injection of Diamox (Acetazolamide) apparently causes increase of the cerebral blod flow with out dilation of the arteries. We wish to study the precise effect of GTN and diamox on the cerebral haemodynamics such as Cerebral blod flow (CBF) and Cerebral blod volume (CBV) via a 3-Tesla MRI.
Interventions
DRUGGTN, Diamox
Sponsors
Danish Headache Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
ECT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy volunteers; men and women age 18-50 years. * weight 50-100 kg
Exclusion criteria
* Tension type headache more then once per month during the last year. * Other primary headache types. * Daily use of medication. * Pregnant or lactating women. * Headache on the trail day or 24 hours prior to the trial. * Contraindications to MRI. * Hypotension og hypertension. * Other significant medical conditions judged by the doctor in charge.
Countries
Denmark
Contacts
Primary ContactMohammad Sohail Asghar, MD
Outcome results
None listed