Acute Myocardial Infarction
Conditions
Keywords
stem cell, acute myocardial infarction
Brief summary
This study is aimed to assess the effect of bone marrow cells on arrhythmia risk variables in patients with a acute myocardial infarction.
Detailed description
This is a randomized, double-blinded study, where patients treated with thrombolytic therapy for acute myocardial infarction are randomized to receive bone-marrow derived stem cells or sham-infusion at the time percutaneous coronary intervention of the target vessel. The end-points are many arrhythmia risk variables, suchs as heart rate variability, T-wave alternans and many ECG variables as well as systolic and diastolic left ventricular function.
Interventions
PROCEDUREintracoronary injection of bone marrow cells
Sponsors
University of Oulu
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Acute ST-elevation myocardial infarction treated with thrombolytic therapy
Exclusion criteria
* Indication for rescue PCI, severe clinical heart failure, age \<18 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arrhythmia risk variables | — |
| left ventricular function | — |
| restenosis assessed by IVUS | — |
Secondary
| Measure | Time frame |
|---|---|
| exercise tolerance | — |
Countries
Finland
Outcome results
None listed