Hypercholesterolemia, Type 2 Diabetes
Conditions
Keywords
type 2 diabetes, lignans, flaxseed, cholesterol
Brief summary
The purpose of the study is to improving the lipid profile and glucose control in type 2 diabetic patients with supplementation of flax lignans. We hypothesize that flax lignans supplement will improve the cholesterol profile and glucose control in type 2 diabetic patients.
Detailed description
The prevalence of type 2 diabetes is increasing dramatically in the last decade in China. Hyperlipidemia is a comorbid condition in type 2 diabetes and increase the adverse health outcomes. Flax lignans, a phytoestrogen found in flaxseed is thought to be the compound responsible for cholesterol-lowering effect of flaxseed. Our purpose is to improving the lipid profile in type 2 diabetic patients with supplementation of flax lignans.
Interventions
DRUGflax lignans
Sponsors
Chinese Academy of Sciences
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
50 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosed type 2 diabetes * Age: 50-79 years old * LDL-cholesterol more than 2.9 mmol/l
Exclusion criteria
* Current or previous (within 6 months) use of estrogen therapy * Cancer * Chronic gastrointestinal diseases * Current use of antibiotics * Any severe liver or renal diseases * Systolic blood pressure more than 180 mmHg or phase 3 hypertension * Any severe mental diseases * Severe cardio- or cerebro-vascular diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total cholesterol at 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| LDL and triglycerides at 3 months; Blood glucose and HbA1C at 3 months | — |
Countries
China
Outcome results
None listed