Blood Collection From Individuals With Lung Disease for Genetic Studies

Collection of Blood for Gene Expression/Genomic Studies in Individuals With Chronic Lung Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00362739

Enrollment

3087

Registered

2006-08-10

Start date

2005-09-30

Completion date

2015-08-31

Last updated

2016-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma, COPD, Cystic Fibrosis, Interstitial Lung Disease, Lung Cancer

Brief summary

This is a research study where researchers are collecting blood to evaluate the genetic characteristics of individuals with chronic lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, cystic fibrosis, and lung cancer.

Detailed description

The investigators hope to be able to identify an association between a genetic make-up in the blood samples and the risks of developing a particular lung disease, or severity of a lung disease. The findings of this study might be important to develop future preventative methods and potential treatments for the management of lung disease. The investigators aim to collect blood samples from 300 people with lung disease and 300 controls over 5 years.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Must provide informed consent * Males and females, age 18 years and older * Lung disease proven by at least one of the following: * symptoms consistent with pulmonary disease * chest X-rays consistent with lung disease * pulmonary function tests consistent with lung disease * lung biopsy consistent with lung disease * family history of lung disease * disease of organs with know associated with lung disease * individuals suspected of history of lung disease based on history and/or physical examination * normal controls (individuals without history of lung disease) to be sampled to provide a comparison to the lung disease cohort.

Exclusion criteria

* Drug and/or alcohol abuse within the past six months * Females who are pregnant or nursing

Design outcomes

Primary

Measure	Time frame
Establish a set of normal ranges for various parameters in healthy individual specimens and compare to specimens from individuals with lung disease to determine parameters resulting in disease susceptibility and severity.	5 years

Countries

United States

Outcome results