Acne Vulgaris
Conditions
Brief summary
The concept behind our study was to combine an effect of antibiotic and anti-inflammatory agents for a more efficient acne therapy directed at the factors involved in the pathophysiology of the disease. For this purpose we evaluated a combination of clindamycin phosphate and salicylic acid in a non-irritating carrier.
Interventions
Sponsors
Hadassah Medical Organization
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Inclusion criteria
* mild to moderate acne vulgaris; * at least 5 lesions on the face; * a one-month wash-out period was established for any topical or systemic drug use for treatment of acne vulgaris.
Exclusion criteria
* acne that was primarily truncal, nodular, or due to secondary causes/internal disease; * pregnancy, breastfeeding, or intention to become pregnant; * another dermatological disease of the face; * significant systemic disease; * any drug/alcohol addiction; * interacting medication; * known hypersensitivity to study medications; * history of chronic disease treated with medications which might affect acne condition and treatment outcome (e.g. corticosteroids, lithium, isoniazid, anti-androgens, phenytoin, phenobarbital) in the preceding month
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lesions count at the baseline (week 0) | — |
| Lesions count at the end of study (week 8) | — |
Countries
Israel
Outcome results
None listed