Heart Failure, Congestive
Conditions
Keywords
Heart failure, pulmonary edema, ACE-inhibitors, lung diffusion, exercise capacity, Chronic heart failure
Brief summary
In patients with chronic heart failure ACE-inhibitor treatment improves lung diffusion and prevents pulmonary edema after fluid overload. In the western country, 3 population types of ACE genotypes exist (DD, ID, II). It is unknown whether the ACE genotype influences the response to fluid overload in ACE-inhibitor treated chronic heart failure patients.
Detailed description
Patients with chronic heart failure in stable clinical condition treated with ACE-inhibitors, but not aspirin, will be evaluated by means of maximal cardiopulmonary exercise test and lung function including lung diffusion measurements. These tests will be done before and after rapid 500 ml isotonic saline infusion. Patients will be grouped according to their ACE genotype.
Interventions
Sponsors
Piergiuseppe Agostoni
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* New York Heart Association (NYHA) class I and II heart failure * Chronic ACE-inhibitor treatment
Exclusion criteria
* Aspirin treatment in the previous 2 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Possible identification of a genetic pattern responsible for different responses to ACE-inhibition during fluid overload in heart failure | Third day |
Secondary
| Measure | Time frame |
|---|---|
| Influence of ACE-genotype on exercise capacity | Third day |
| Influence of ACE-genotype on lung function | Third day |
Countries
Italy
Outcome results
None listed