Hepatocellular Carcinoma
Conditions
Keywords
HCC, operation, percutaneous ethanol injection
Brief summary
The purpose of this study is to choose the preferred treatment modality for solitary, small hepatocellular carcinoma.
Detailed description
To compare the below things between operation group and percutaneous ethanol injection therapy (PEIT) group: 1. Survival * 5 year overall survival rate * Disease free survival rate 2. Recurrence * Cumulative recurrence rate
Interventions
PROCEDUREOperation
No drug needed
99% ethanol, 2-4cc per one session, two to three sessions per single procedure for one week
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* The evidences of hepatitis B virus (HBV)&/or hepatitis C virus (HCV) infection or liver cirrhosis * Single tumor nodule with Child-Pugh classification A (serum albumin ≥ 3.2 g/dL) * The maximal, longest diameter of tumor mass measured by CT finding should be less than 2 cm * Only for the newly detected HCCs which were not treated before * It should be compatible with the typical finding of hepatocellular carcinomas (HCCs) radiologically (MD CT or dynamic MRI) * Without portal hypertension
Exclusion criteria
* In case of hepatic vein or portal vein invasion radiologically (CT or MRI)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall survival rate | 5 year |
Secondary
| Measure | Time frame |
|---|---|
| disease free survival rate and recurrence rate | 5 year |
Countries
South Korea
Outcome results
None listed