Atrial Fibrillation and the Risk for Neurological Complications

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00357227

Enrollment

1000

Registered

2006-07-27

Start date

2004-01-31

Completion date

Unknown

Last updated

2007-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation

Keywords

Atrial fibrillation, Stroke, Vascular Dementia, Mild Cognitive Impairment

Brief summary

B8: Atrial fibrillation and the risk of neurological complications Twenty-five thousand acute strokes are caused by atrial fibrillation every year. But even more frequent than symptomatic strokes are silent infarctions of the brain. Silent strokes remain undetected in most cases, but cumulate over time and progressively impair cognition. The impact of atrial fibrillation on subacute brain infarctions is not yet known. Moreover, it has not been elucidated so far how effective different therapeutic strategies in the treatment of atrial fibrillation prevent cognitive impairment. Thus, this study aims at evaluating the influence of different types of atrial fibrillation on silent strokes and the related impairment in cognitive functions. Other risk factors and cardiovascular diseases that are known to provoke the development of strokes will be assessed as well. So, it will be possible to isolate the contribution of atrial fibrillation to silent strokes and related cognitive impairment in segregation to other relevant factors. AF patients and controls will be examined twice in two years in order to evaluate the role of atrial fibrillation and differential therapeutic interventions with regard to the progression of silent strokes and cognitive impairment in a within subject-design.

Interventions

None listed

Study design

Observational model

DEFINED_POPULATION

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

50 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

* Clinical diagnosis of permanent, paroxysmal or episodic atrial fibrillation in the past or at present

Exclusion criteria

* Pacemaker * Metal implants * History of acute stroke * Diagnosis of vascular or degenerative dementia * History of brain tumors * History of severe brain injury * History of psychiatric disorders * Pregnancy

Countries

Germany

Contacts

Primary ContactStefan Knecht, Prof.

knecht@uni-muenster.de+49-251-83-

Outcome results