Kidney Failure
Conditions
Keywords
Kidney failure, Contrast media, Antioxidant, Prevention
Brief summary
The contrast induced nephropathy (CIN) has been known to be associated with significant clinical and economic consequences. Many studies were performed to find the pathophysiology and preventive measures for CIN. But the results were somewhat frustrating. Recently, it has been reported that the N-acetylcysteine and ascorbic acid might have preventive effects for CIN by their antioxidant effects.There have been no study to compare these two antioxidant.
Detailed description
N-acetylcysteine and ascorbic acid may prevent the CIN in the patients with underlying renal insufficiency who is undergoing the coronary angiography. The effect may derive from the antioxidant function of these two antioxidant. We studied to find which of the two antioxidants is more beneficial in prevention of CIN
Interventions
DRUGN-acetylcystein
DRUGascorbic acid
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Stable Angina pectoris patients * Patients who required the coronary catheterization * Creatinine clearance rates =\<60 mL/min using the Cockcroft-Gault formula * Age of 19 or over 19
Exclusion criteria
* Pregnancy * Lactation * Having received contrast media within 7 days of study entry * Emergent coronary angiography * Acute renal failure * End-stage renal disease requiring dialysis * History of hypersensitivity reaction to contrast media * Cardiogenic shock * Pulmonary edema * Multiple myeloma * Mechanical ventilation * Parenteral use of diuretics * Recent use of N-acetylcysteine * Recent use of Ascorbic acid * Recent use of statin * Use of metformin or nonsteroidal anti-inflammatory drugs within 48 hours of the procedure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The mean peak increase of serum creatinine concentration during day1 and day2. | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of contrast induced nephropathy, defined as either a relative increase in serum creatinine | — |
| from baseline of >=25% or an absolute increase of >=0.5mg/dL(44.2µmol/L) during days 1 and 2. | — |
| Proportion of patients exhibiting an increase in serum creatinine of >=0.5mg/dL(44.2µmol/L) | — |
| proportion with a >=1.0 mg/dL(88.4µmol/L) increase in serum creatinine; | — |
Countries
South Korea
Outcome results
None listed