The Effects of Clonidine on the Diuretic Response in Cirrhotic Patients

The Effects of Clonidine on the Diuretic Response in Cirrhotic Patients With Ascites and Activation of Sympathetic Nervous System: a Randomized Double-Blind Placebo Controlled Study.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00356226

Enrollment

Registered

2006-07-25

Start date

2000-10-31

Completion date

Unknown

Last updated

2006-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ascitic Cirrhosis, Hyperactivation of Sympathetic Nervous System

Keywords

norepinephrine, renin, aldosterone, hemodynamics, spironolactone

Brief summary

To examine the effects of the addition of clonidine to diuretics on the mobilization of ascites at short-term (diuretic response and requirement of diuretics) and long-term (readmissions for tense ascites and requirement of diuretics) in cirrhotics with increased sympathetic nervous system. Secondary objectives were to study neuro-hormonal,hemodynamic effects and side effects of clonidine and diuretics.

Interventions

DRUGclonidine

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Cirrhotic patients with ascites * Plasma norepinephrine level \> 300 pg/mL (normal value: 185 - 275 pg/mL)

Exclusion criteria

* Serum bilirubin concentration above 4.5 mg/dL * Prothrombin time below 40% * Platelet count below 40 X 10¨9/liter * Serum creatinine concentration above 2 mg/dL * Gastro-intestinal hemorrhage * Alcoholic hepatitis * Diabetes mellitus, * Hepatocellular carcinoma * Respiratory or cardiac failures * Hepatic encephalopathy * Bacterial infection

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026