Dystonia, Movement Disorders, Parkinson Disease, Parkinsonian Disorders, Tourette Syndrome
Conditions
Keywords
Deep brain stimulation, Microelectrode recordings, Basal Ganglia, Sedation, Propofol
Brief summary
The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to sedation during deep brain stimulation surgery.
Detailed description
Deep Brain Stimulation is commonly used for the treatment of movement disorders. Electrode positioning is usually performed under local anesthesia in fully awake patients. The procedure is uncomfortable to the patients who have to remain motionless during the whole surgery. Previous reports of electrode positioning under general anesthesia was found to be less accurate. This result was probably due to the effect of the anesthetics on the electrical activity of the Basal Ganglia. The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to propofol sedation. Electrical activity of single neurons will be recorded before and after sedation.
Interventions
PROCEDURESedation with IV propofol
Propofol(50 microgram/kg/min.), I.V. for 5-10 minutes, Until a level of light sedation is achieved
Sponsors
Hadassah Medical Organization
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Candidate for Deep Brain Stimulation Surgery. * Informed concent obtained.
Exclusion criteria
* Suspected difficult intubation (by history or physical examination). * Allergy to Propofol, eggs or soy-beans. * History of sleep apnea syndrome.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in the electrical activity of neuron cells of the basal ganglia in the examined patients | Within 24 hours needed to analyse the data |
Countries
Israel
Outcome results
None listed