Blood Pressure, High, Hypertension
Conditions
Keywords
Hypertension, High Blood Pressure, Diuretic, Angiotensin converting enzyme inhibitor, Ambulatory blood pressure monitoring
Brief summary
The purpose of this study is to determine if there is greater blood pressure reduction using ramipril or hydrochlorothiazide alone or ramipril and hydrochlorothiazide together.
Interventions
DRUGRamipril and hydrochlorothiazide
Sponsors
Pfizer
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Previously diagnosed, or newly diagnosed essential hypertension. Blood pressure must be within a minimum and maximum range prior to drug treatment.
Exclusion criteria
* Inability to discontinue all prior antihypertensive medications * Heart failure * History of stroke, myocardial infarction, or chest pain within 3 years, or an abnormal heart rhythm * Liver or kidney disease * Certain drugs used to treat other conditions like an enlarged prostate gland, or arthritis * Allergy or reactions to certain medications used to treat high blood pressure Other protocol-defined inclusion and
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Compare the effects on sitting diastolic blood pressure of two antihypertensive drugs in combination against each antihypertensive alone after an eight week treatment period. | — |
Secondary
| Measure | Time frame |
|---|---|
| Compare the effect on sitting diastolic blood pressure of two antihypertensive drugs in combination taken once daily against one antihypertensive drug taken twice daily. | — |
| Compare the effect on sitting diastolic blood pressure of a dose of an antihypertensive drug taken once daily against half of the same dose taken twice daily. | — |
| Compare the effect on the sitting and standing blood pressure among all treatment groups. | — |
| Compare the safety of each medication regimen stated above. | — |
| Compare the effect on mean 24-hour diastolic blood pressure (ABPM) of the medication regimens stated above. | — |
Countries
United States
Outcome results
None listed