Arterial Stiffness, Wave Reflections and Renal Failure

Observational Study on the Prognostic Significance (Renal and Cardiovascular) of Arterial Stiffness and Arterial Wave Reflections in Patients With Mild to Moderate Renal Impairment

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00354588

Enrollment

115

Registered

2006-07-20

Start date

2006-01-31

Completion date

2010-10-31

Last updated

2010-11-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arterial Stiffness, Arterial Wave Reflections, Chronic Renal Failure

Keywords

chronic renal failure, arterial stiffness, arterial wave reflections

Brief summary

1. Cardiovascular risk is high in patients with renal failure. 2. Cross-sectional studies have indicated a relationship between arterial stiffness and renal function. However, there are no prospective longitudinal studies in the literature. 3. In dialysis patients, arterial stiffness as well as wave reflections, predict mortality. However, there are no data on patients with mild-to-moderate renal impairment available. 4. Therefore, we designed a study to test the hypothesis that: a) measures of arterial stiffness and wave reflections predict the progression of renal impairment in patients with mild-to-moderate renal failure; and b) measures of arterial stiffness and wave reflections predict cardiovascular events in patients with mild-to-moderate renal failure

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

19 Years to No maximum

Healthy volunteers

Inclusion criteria

* chronic renal failure patients (KDOQI III, IV) undergoing regular control visits at our nephrology department * \> 19 years * written informed consent

Exclusion criteria

* atrial fibrillation * valvular heart disease * severely impaired systolic function * no informed consent

Design outcomes

Primary

Measure	Time frame	Description
renal endpoint	—	doubling serum creatinine, need for dialysis, renal transplantation

Countries

Austria

Outcome results