Arteriosclerosis, Coronary, Atherosclerosis, Coronary, Coronary Arteriosclerosis, Coronary Artery Disease, Coronary Atherosclerosis
Conditions
Keywords
MESA, MRI, Cardiovascular, Cardiac, Coronary, Atherosclerosis
Brief summary
The overall goal of this study is to use MRI to: * Examine the relationship between known risk factors for cardiovascular disease and coronary artery wall thickness; * Examine the relationship between coronary artery wall thickness and other markers of subclinical coronary atherosclerosis, such as carotid wall thickness and coronary calcium scores; and, * Examine the feasibility of measuring the progression of coronary artery wall thickness over time in a subset of participants.
Detailed description
Each enrolled participant will undergo MR Imaging of the coronary arteries in conjunction with their routine MESA follow-up visit. The MRI will last approximately 45-60 minutes
Interventions
PROCEDUREMR Imaging of the Coronary Arteries
Sponsors
Northwestern University
Johns Hopkins University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
45 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Prior enrollment in the MESA Study at the Hopkins MESA Field Center or the Northwestern University MESA Field Center * Male or Female adult equal to or older than 45 years of age * Willing/able to provide informed consent
Exclusion criteria
* Any known contraindications to MRI (i.e. severe claustrophobia, pacemaker, etc.) * Metal in the eyes
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean Coronary Wall Thickness | n/a (cross sectional analysis) | Average thickness of the wall of the left anterior descending, right and left main coronary artery measured by magnetic resonance imaging (MRI). |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Participants Participants in the MESA trial (http://www.mesa-nhlbi.org/) randomly selected by the University of Washington Coordinating center who agreed to participate. Enrollment from October 2005 to February 2008 | 179 |
| Total | 179 |
Baseline characteristics
| Characteristic | Participants |
|---|---|
| Age, Categorical <=18 years | 0 Participants |
| Age, Categorical >=65 years | 0 Participants |
| Age, Categorical Between 18 and 65 years | 179 Participants |
| Age Continuous | 61 years STANDARD_DEVIATION 9 |
| Region of Enrollment United States | 179 participants |
| Sex: Female, Male Female | 90 Participants |
| Sex: Female, Male Male | 89 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | — / — |
| other Total, other adverse events | 0 / 179 |
| serious Total, serious adverse events | 0 / 179 |
Outcome results
Primary
Mean Coronary Wall Thickness
Average thickness of the wall of the left anterior descending, right and left main coronary artery measured by magnetic resonance imaging (MRI).
Time frame: n/a (cross sectional analysis)
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Participants | Mean Coronary Wall Thickness | 2.0 mm | Standard Deviation 0.3 |