Healthy
Conditions
Keywords
no specific conditions
Brief summary
In the Netherlands fortification of food products is not yet mandatory. One of the major arguments of the Dutch Health Council to advise against mandatory fortification is the possibility of masking of a vitamin B12 deficiency. A possible solution to overcome the possibility of masking is: fortification of foods with both folic acid and vitamin B12. In this study we want to assess the effects of this fortification strategy on markers of folate and vitamin B12 status.
Detailed description
During a 12 week period subjects will consume * bread fortified with folic acid and vitamin B12 or * placebo bread (not fortified) Bread consumption has to be at least 3 slices per day, fortification level is 100mcg folic acid and 6mcg vitamin B12 per 3 slices. We will study the effect of this fortification strategy on markers of folate and vitamin B12 status.
Interventions
PROCEDUREconsumption of fortified bread
Sponsors
Wageningen Centre for Food Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
50 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* age 50-75y
Exclusion criteria
* consumption of \< 3 slices of bread/day * use of B-vitamins in the period three months prior to the study * treatment with B12-injections in the last 5y * illness or use of medication interfering with folate or vitamin B12 metabolism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum B12 status | — |
| serum folate status | — |
Secondary
| Measure | Time frame |
|---|---|
| erythrocyte folate; | — |
| homocysteine; | — |
| MMA; | — |
| holoTC | — |
Countries
Netherlands
Outcome results
None listed