Myoma
Conditions
Keywords
embolization, contrast enhanced ultrasound, myoma, uterine artery, microvascularisation
Brief summary
Contrast-enhanced ultrasound is supposed to improve the detection of myomas as well as improve the follow-up after specific treatments like embolization. It will also help the investigators better understand the mechanism of success or failure for embolization and could reduce the amount of particles injected by determining the endpoint of the procedure in order to treat the myomas while preserving the myometrium.
Detailed description
Before embolization of the uterine artery, 40 patients with unique or multiple myomas will be included prospectively in our study and evaluated with sonography before and after injection of Sonovue (2.4 ml) (Bracco Int Milano Italy). Pelvic ultrasound with contrast enhancement will be done the day after and six months after the procedure. Microvascularization of the myomas and the endometrium will be described. Some tiny myomas which are not visible on conventional sonography could be identified for a perfect matching with MRI detection.
Interventions
PROCEDUREcontrast enhanced ultrasonography
Three contrast-enhanced ultrasonography : before embolization, after one day and after 6 months. Abdominal route 2.4 ml sonovue per injection / bolus
PROCEDUREembolization
Intervention is described in the case report form for each patient
Sponsors
University Hospital, Tours
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Uterine myomas with solid tissue (greater diameter lower than 15 cm) * The embolization is planified during the 15 days after the contrast ultrasonography * Written informed consent is signed
Exclusion criteria
* Intracavitary uterine mass possibly due to a polyp or endometrial cancer * Necessity of using the endovaginal way of ultrasonography because of the myoma's size and accessibility * Menopause * Pregnancy and breastfeeding * Recent cardiac affection * History of acute cardiac disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To investigate the usefulness of contrast-enhanced ultrasound with real-time imaging technique in the assessment of vascular patterns from myomas myometrium and ovaries before and after uterine artery embolization | Inclusion period and follow-up |
Secondary
| Measure | Time frame |
|---|---|
| Accordance between contrast-enhanced imaging and IRM | inclusion period and follow-up |
| Accordance between early vascular patterns due to embolization of the fibroma and the success of the technique which is evaluated after 6 month | inclusion period and follow-up |
| Relationship between the post embolization pain and the vascular change of the fibroma and the myometrium | inclusion period |
Countries
France
Contacts
Primary ContactHenri MARRET, Pr
Backup ContactCatherine ROUSSEL, ARC
Outcome results
None listed