Schizophrenia
Conditions
Keywords
fMRI, Visual perception, Attention
Brief summary
The main objective of the study is to contribute to a better understanding of the physiopathology of schizophrenia, by studying causal relationships between cognitive deficits and the neurobiological basis for these deficits. Processing visual information involves both automatic grouping processes and control processes. Automatic grouping processes allow the building of a global configuration from local contour information. It is necessary in order to recognize objects. Control processes allow tending to and prioritizing information parts. The paradigm the investigators use allows to dissociate these processes, and is used in order to characterize the impairments observed in patients with schizophrenia. It is adapted to fMRI in order to explore the neurobiological basis of the deficits. The investigators will examine whether functional disconnectivity between activated areas subtend the impairments observed in patients.
Interventions
PROCEDUREfMRI
One 30 minute session
Sponsors
Institut National de la Santé Et de la Recherche Médicale, France
Centre National de la Recherche Scientifique, France
Région Alsace
Faculté de Médecine de Strasbourg
University Hospital, Strasbourg, France
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients with schizophrenia (DSM-IV criteria) * Healthy controls matched with patients on age, sex and education level * Ages 18 to 50 * Signed informed consent * Right-handed
Exclusion criteria
* No severe somatic illness * No invalidating sensory disease * No drug abuse, as defined by DSM-IV criteria * No general anaesthesia in the past 3 months * No intake of drugs affecting the CNS, except for patients
Countries
France
Outcome results
None listed