Schizophrenia
Conditions
Keywords
Schizophrenia, Time perception, Cortical synchronization, Electroencephalography
Brief summary
Abnormalities in the ability to distinguish events in time may have a great impact on everyday life. The main objective of the study is to evaluate the magnitude of the temporal windows in schizophrenia, i.e. the time interval during which two events are perceived as synchronous. The investigators test the hypothesis that these temporal windows are enlarged, and check the relationship between this impairment and disorganization symptoms, in order to explore the link between this cognitive impairment and clinical symptoms. They explore also the neurobiological bases of the impairment by means of electroencephalogram (EEG) recordings. Event-related potentials (N50) will reveal whether or not the coding of the stimuli has the same temporal characteristics in patients and controls. The distribution and amplitude of oscillatory activities will be analyzed as a function of the synchronous or asynchronous response of the subject, thus allowing to explore the links between synchrony perception and neuronal synchronization phenomena.
Interventions
PROCEDUREEEG
One 20 minutes session
Sponsors
Institut National de la Santé Et de la Recherche Médicale, France
Centre National de la Recherche Scientifique, France
Institut de Physique Biologique de Strasbourg
University Hospital, Strasbourg, France
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients with schizophrenia (DSM-IV criteria) * Healthy controls matched with patients on age, sex and education level * Age between 18 and 50 * Informed consent signed * No severe somatic illness * No invalidating sensory disease * No drug abuse, as defined by DSM-IV criteria * No general anesthesia in the past 3 months * No intake of drug affecting the CNS, except for patients
Countries
France
Outcome results
None listed