Does Sildenafil Protect Against Pulmonary Related Complications Following Cardiopulmonary Bypass?

A Randomised, Double-Blind, Placebo-Controlled, Single-Centre Study of the Pre-Operative Effect of Sildenafil Citrate on Pulmonary Related Complications Following Cardiopulmonary Bypass in Children Undergoing Cardiac Surgical Repair.

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00350441

Enrollment

Registered

2006-07-10

Start date

2006-06-30

Completion date

Unknown

Last updated

2006-10-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiopulmonary Bypass

Keywords

Sildenafil Citrate, Cardiopulmonary bypass, Open heart surgery

Brief summary

Does pre-operative administration of Sildenafil (Viagra, Pfizer) reduce the lung injury associated with cardiopulmonary bypass in children undergoing corrective surgical repair of congenital heart disease.

Interventions

DRUGSildenafil Citrate

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

3 Months to 5 Years

Healthy volunteers

Inclusion criteria

Paediatric patients undergoing open heart surgery utilising cardiopulmonary bypass to correct acyanotic congenital heart disease. Age \> 3 months Parents that show a good understanding of their child's condition and are happy for their child to participate in the study.

Exclusion criteria

Patients with known organ dysfunction prior to surgery (pulmonary, renal or hepatic) Communication barrier resulting in poor basic comprehension of the proposed study (e.g. language barrier) Patients with cyanotic heart disease Patients undergoing heart surgery without the use of cardiopulmonary bypass Patients who do not tolerate oral Sildenafil (e.g. Vomiting) or whose surgery is subsequently cancelled.

Countries

United Kingdom

Contacts

Primary ContactTony Vassalos, MB Ch B

tonyv@doctors.org.uk0141 201 1000

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026