The Effect of High Dose Vitamin C in Burn Patients

The Effect of High Dose Versus Low Dose Intravenous Vitamin C (Ascorbic Acid)on Burn Injury Resuscitation

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00350077

Acronym

Vitamin C

Enrollment

Registered

2006-07-10

Start date

2006-07-31

Completion date

2008-03-31

Last updated

2011-12-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Burns

Keywords

Burns

Brief summary

The purpose of this study is to see if intravenous Vitamin C will decrease the amount of IV fluids needed following burn injury in the first 48 hours.

Detailed description

Adequate fluid resuscitation in burn injured patients to allow adequate renal blood flow has been the hallmark of burn care in the last 50 years. The danger of exceeding the optimal intravenous fluid resuscitation has resulted in severe complications including abdominal compartment syndrome, loss of upper airway control, extremity compartment syndromes and pulmonary edema. Hig dose vitamin C infusion during the first 24 hours of burn resuscitation has been documented to decrease the overall amount of intravenous fluid needed to provide for adequate renal perfusion and hemodynamic stability in multiple animal model studies. High dose vitamin C is thought to decrease postburn microvascular protein and fluid leakage by reducing postburn lipid oxygenation caused by burn injury generated free radicals.

Interventions

DRUGIntravenous Vitamin C

vitamin C IV during 24 hour period following burn

DRUGVitamin C

IV vitamin C

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 72 Years

Healthy volunteers

Inclusion criteria

* \>/= 20% total body surface area full and partial thickness burns * Admitted to the USAISR burn center within 10 hours post injury

Exclusion criteria

* Pregnant or breast feeding * Documented preadmission or admission renal failure * History of glucose-6-phosphate dehydrogenase deficiency, kidney stoves, gout or sickle cell * Electrical injury * Renal replacement of any kind\<24 hours after admission

Design outcomes

Primary

Measure	Time frame
Document a significantly lower intravenous fluid requirement per percent total body surface area burn in the High Dose Vitamin C group	72 hours
Document a significantly higher number of mechanical ventilator free days	7 days
Document a significantly lower complication and infection rate in the Vitamin C group	7 days
Document decreased lipid peroxidation by monitoring serum malondialdehyde (MDA) level	72 hours

Secondary

Measure	Time frame
Document a lower incidence of organ failure	30 days

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026