Profile of Depressive Symptoms in Parkinsons Disease

Profile of Depressive Symptoms in Parkinson's Disease (PRODEST-PD)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00349310

Enrollment

1018

Registered

2006-07-06

Start date

2006-04-01

Completion date

2006-10-01

Last updated

2023-12-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression, Parkinson Disease

Brief summary

To explore or establish the relationship between cognitive, mood and motor symptoms in PD to scores on depression rating scales in a naturalistic setting.

Interventions

DRUGPramipexole

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Inclusion\_Criteria: Observation criteria: * are able to provide written informed consent in accordance with Good Clinical Practice (GCP) and local legislation * have idiopathic Parkinsons disease according to the United Kingdom Parkinsons Disease Society Brain Bank Diagnostic Criteria for Parkinsons disease * show no impairment of cognitive function (MMSE score ?24) * are with or without symptoms of depression (full range) * are stable on anti-Parkinson/anti-depressive treatment for at least 1 month before entering the study * are or are not on concomitant antidepressant treatment * are in the on state during the observation period * did not previously undergo PD surgery

Design outcomes

Primary

Measure	Time frame
HADS, HAMD-17, BDI-1A, FAB (cognitive), DSM-IV (mood- part A, B, C, E) and UPDRS	Up to 6 months

Countries

Austria, France, Germany, Italy, Netherlands, Spain, Switzerland, United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026