Type 1 Diabetes
Conditions
Keywords
Vascular abnormalities, Type 1 diabetes, Healthy control subjects
Brief summary
The objectives of this investigator initiated study are to: 1. Determine if and when vascular abnormalities occur during early adolescence 2. Determine if poor diabetic control is related to vascular abnormalities. The development of vascular plaques and vascular contractility will be assessed through the use of the SyphmgnoCor equipment.
Detailed description
Up to 85 Type 1 diabetic and healthy controls, 12-14 years of age, will be recruited for the study. Once the Permission/Assent form has been completed, a cuff will be applied to the arm and the pressure tonometer will be used on various vessels. Cardiovascular data will be recorded. The procedure is non-invasive, will last approximately 10 minutes and will be performed during a routine clinic visit. Onset of diabetes and level of diabetic control as measured by the most recent Hbg A1c (relative to the study visit) will be obtained from the medical record. Microalbumin levels covering the prior 12 months will be collected from the medical record of diabetic subjects.
Interventions
PROCEDUREMeasurement of vascular function per SphymgnoCor equipment
Pressure tonometer will be used on various vessels, non-invasive.
Sponsors
Children's Mercy Hospital Kansas City
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
12 Years to 14 Years
Healthy volunteers
Yes
Inclusion criteria
* Boys and girls ages 12-14 years who have Type 1 diabetes or are healthy controls
Exclusion criteria
* Children and adolescents who do not meet inclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vascular abnormalities as measured by the SyphmgnoCor equipment | End of study |
Countries
United States
Outcome results
None listed