Effectiveness of a Procedure for Previously Failed Glaucoma Surgery

Efficacy of Transconjunctival Mitomycin-C in Needle Revisions of Failing Trabeculectomy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00347789

Enrollment

100

Registered

2006-07-04

Start date

1997-05-31

Completion date

2006-06-30

Last updated

2006-07-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma

Keywords

glaucoma, trabeculectomy, filtering bleb revision, intraocular pressure, needling procedure, mitomycin C

Brief summary

Transconjunctival mitomycin-C in needle bleb revision may be an effective procedure to treat cases with a previously failed trabeculectomy. We will investigate approximately 100 consecutive cases with follow up of up to 9 years. We anticipate that this procedure is an effective, safe, and appropriate option for successful glaucoma treatment.

Detailed description

The healing process after filtering surgery for glaucoma may cause an unsuccessful outcome for the trabeculectomy procedure. In order to control the rising intraocular pressure due to the failed trabeculectomy, medications may be restarted and/or filtering surgery may need to be repeated. Our primary research showed that transconjunctival mitomycin-C in needle bleb revision may be an effective procedure to control this situation. This retrospective study will follow over 100 patients from May 1997 to May 2006. This long-term follow up will help assess the future role of this technique in glaucoma practices.

Interventions

PROCEDUREGlaucoma surgery- Bleb revision

Study design

Observational model

DEFINED_POPULATION

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

0 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Diagnosis of glaucoma * Failed filtering procedures- defined as intraocular pressure exceeded target pressure thus inducing possible further optic nerve damage

Exclusion criteria

\- Needling combined with other ocular surgical or laser treatments

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026