AIDS, HIV Infection
Conditions
Keywords
Lopinavir, Pharmacokinetic, Pharmacodynamic, Ethiopian population, Caucasian population
Brief summary
The objective of this proposal is based on the assumption that the HIV infected Ethiopian population responded in a different way in comparison to the Caucasian subjects to Lopinavir therapy. Our preliminary data demonstrated that Ethiopian's have different Lopinavir serum concentration in comparison to non-Ethiopian's. For these reasons the plan of this study is to investigate the pharmacokinetic/pharmacodynamic (PK/PD) profile in both populations. The results will allow to establish a better personalised medicine for HIV infected individuals.
Detailed description
The objective of this proposal is based on the assumption that the HIV infected Ethiopian population responded in a different way in comparison to the Caucasian subjects to Lopinavir therapy. Our preliminary data demonstrated that Ethiopian's have different Lopinavir serum concentration in comparison to non-Ethiopian's. For these reasons the plan of this study is to investigate the pharmacokinetic/pharmacodynamic (PK/PD) profile in both populations. The results will allow to establish a better personalised medicine for HIV infected individuals.
Interventions
DRUGLopinavir pharmacokinetic/pharmacodynamic analysis
Sponsors
Ministry of Health, Israel
Rambam Health Care Campus
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* All HIV infected Ethiopian and Non-Ethiopian subjects * AIDS diseased Ethiopian and Non-Ethiopian individuals
Exclusion criteria
* Individuals who are unable to sign the informed concent * Individuals unable to take oral medications * Individuals who described Lopinavir allergy
Countries
Israel
Outcome results
None listed