Frozen Thawed Embryo Transfer
Conditions
Keywords
endometrial preparation, Utrogestan, Endometrin
Brief summary
The transfer of frozen-thawed embryos can be performed in a natural ovulatory cycle or in a hormonally manipulated cycle with a comparable pregnancy rate of 15%-20% per ET. When a hormonally modulated ET cycle is scheduled,an artificial endometrial preparation is carried out using estrogen stimulation followed by a concomitant progesterone treatment. Two progestative drugs are currently used in conventional IVF treatment, Utrogetan and Endometrin. Although Endometrin has been be efficiently used to support the luteal phase after embryo transfer in IVF cycles, currently, there is no study that assess its efficacy for clinical use in frozen-thawed ET cycles. The present study aims to compare the outcome of frozen thawed ET cycles when either Endometrin or Utrogestan are used as the progestative substitution in an artificially prepared endometrium.
Interventions
DRUGComparison between two different progesterone administration
Sponsors
Hadassah Medical Organization
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Inclusion criteria
1. Patients undergoing frozen thawed ET cycles 2. Patient has at least two embryos suitable for transfer after thawing 3. Age 18-35 years -
Exclusion criteria
1. Any known sensitivity to Endometrin or Utrogestan 2. Endometrial thickness less than 7.5 mm after estrogen priming -
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pregnancy rates | — |
Secondary
| Measure | Time frame |
|---|---|
| Lutheal hormonal profile | — |
Countries
Israel
Outcome results
None listed